Lois Griffin was born to affluent WASP parents, Carter and Barbara Pewterschmidt. It is revealed in Family Goy that her mother is actually a Holocaust survivor who concealed her Judaism, making Lois Jewish herself, and retconing her apparently Jewish Long Island and New York accent. Lois is the wife of Peter Griffin and the mother of Meg, Chris and Stewie Griffin. Lois and the rest of the Griffins live in the fictional town of Quahog, Rhode Island which is modeled after Cranston, Rhode Island. Lois primarily works as a housewife throughout the series, though she did give piano lessons in early episodes of the series. Lois has also had various jobs in single episodes such as in "FOX-y Lady", were she becomes the new reporter for Fox News Channel and in "It Takes a Village Idiot, and I Married One", Lois is elected the mayor of Quahog.
Family Guy uses a floating timeline in which the characters do not age much, so the show is always assumed to be set in the current year. However, several of the characters, such as Meg Griffin, have aged two to three years since the show's pilot episode, while others, such as Stewie and Brian, have remained the same age. In several episodes, events have been linked to specific times, although this timeline has been contradicted in subsequent episodes.