Unlike previous Ward series, the animation production was done in Hollywood using veteran animators Phil Duncan, Rod Scribner, and Rudy Zamora, among others. Each segment's theme song was written by the team of Stan Worth and Sheldon Allman, though the cartoons themselves had little or no music scoring, as with Bullwinkle. Ward mainstays Bill Scott, June Foray, and Paul Frees provided most of the character voices over all three segments.
The cartoons are technically more advanced than the crude animation in Ward's earlier series, which originated from a Mexican studio sponsored by Ward. He was so pleased with George of the Jungle that he allowed production to go over-budget, which unfortunately resulted in considerable financial loss, ultimately limiting the series to 17 episodes.