The series centers on Luz Noceda, a Dominican-American human girl who accidentally stumbles upon a portal to the Demon Realm. She arrives at the Boiling Isles, an archipelago formed from the remains of a dead titan, and befriends the rebellious witch Eda Clawthorne, also known as "The Owl Lady", and her adorable demon housemate King. Despite not having magical abilities, Luz pursues her dream of becoming a witch by serving as Eda's apprentice at the Owl House and ultimately finds a new family in an unlikely setting.
In the second season, Luz attempts to return to the Human Realm, Eda tries to confront her curse, and King searches for the truth about his past while contending with the Boiling Isles' ruler, Emperor Belos, who is preparing for the mysterious "Day of Unity".
In the finale specials, Luz and her friends journey to save the Boiling Isles from Belos and the chaotic Collector.