Alexis Rhodes, along with Zane Truesdale and Chazz Princeton, is one of the top students at the Academy. She is regarded as the "Madonna" and Queen of Obelisk Blue, yet she does not follow the crowd nor does she regard herself as better than other people like many of her Obelisk peers.
Alexis mourns for her long-lost older brother, Atticus. With the help of Zane, she constantly searches for clues surrounding his disappearance, until it is revealed that he was brainwashed and joined the Shadow Riders, under the control of Nightshroud. Defeated by Jaden Yuki in a shadow duel and relieved of this persona, the incident leaves Atticus amnesic, prompting his sister to engage in a duel with a Shadow Rider, Titan, to restore his memories. Ultimately, Alexis won and her brother got his memories back.
Later in the series, Chazz comes out about his infatuation with Alexis after Jaden defeats the final Shadow Rider. Atticus helps Chazz with his crush and he steals all seven spirit keys in order to force Alexis to duel with him. Although Chazz plays suggestive cards such as "Hidden Wish" and "Love Letter" to show her how much he cares, Alexis wins in the end, stating that she cannot return his feelings, because she's "in love with dueling". In this duel Alexis introduces her "Cyber Angel" series. Chazz's crush on Alexis continues throughout the series, although after having his free will sapped by Sartorius, his interests fade, until he is rescued by Jaden and returned to his former self.
Following Chazz's entrance into the Society of Light, Alexis duels with him to keep him from taking over Obelisk Blue completely. She fails, however, and meets the same fate as her fellow elites, though she retains her pride as an Obelisk Blue duelist, refusing to play the "White Veil" card given to her by Sartorius in her duel against Maitre' D during the Genex tournament.